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AP - Upscale department store operator Nordstrom Inc. said Thursday that its affluent shoppers continued to spend in the fourth quarter and its profit rose 1.7 percent from a year earlier.
If you have an iPhone 4 you want to DIY color swap, you'll always want to make sure you buy quality parts. While you can't get completely OEM parts, since Apple never manufactured parts in anything other than black and white, you can still snag high quality parts if you know where to look and what to watch for.
I seem to have a theme lately on all my posts. In the last couple of months I have made numerous slow cooker recipe. They are great when my two boys are acting ornery and nothing seems to be getting done. Most of the dishes that I have made have been beef or pork, which are delicious and easy to make in the crockpot. However, I have been trying to branch out and try new vegetarian dishes. The recipes I have tried have been hit or miss, so when I saw a recipe for Slow-Cooker Sweet Potato and Lentil Soup in the December issue of the Food Network Magazine, I figured it was worth a try.
This recipe has 12 ingredients. It takes 25 minutes of prep and eight hours of cooking time in the crockpot and makes 4 servings. I did have a problem finding one of the recipe ingredients. For whatever reason all the major grocery stores in my area refuse to carry any type of lentil other than the basic brown variety. Luckily I discovered when looking for ingredients for this dish that the smaller Lebanese market near my house has bagged red lentils. I was very happy! I had no problems finding any of the other ingredients and made no substitutions. I did find that the finished soup was way too watery for my tastes. I suggest using either chicken broth (or vegetable broth to keep it vegetarian). The broth would add greatly to the overall flavor of the dish. I followed the remainder of the recipe as written.
With only four calories and 12 grams of protein, this dish is a great healthy option. I would definitely suggest adding the broth instead of water. As written the recipe lacks flavor due to the water, with the substitution the recipe would be great. A very easy, vegetarian slowcooker meal that takes less than a half an hour to prepare. Great for a weeknight meal!
For the recipe go to Slow-Cooker Sweet Potato and Lentil Soup.
Sanford-Burnham and Florida Hospital review obesity research progress with Takeda PharmaceuticalPublic release date: 15-Feb-2012 [ | E-mail | Share ]
Contact: Deborah Robison drobison@sanfordburnham.org 407-745-2073 Sanford-Burnham Medical Research Institute
The mid-term report lays groundwork for next phase of study
Orlando, Fla. February 15, 2012 Sanford-Burnham Medical Research Institute (Sanford-Burnham) and Florida Hospital researchers recently returned from Japan where they reviewed the progress that has been made at the mid-point of their research partnership with Takeda Pharmaceutical Company Limited (Takeda). The two-year collaboration focuses on the discovery and evaluation of new therapeutic approaches to obesity. The scientists reported benchmark data that sets the stage for a key element in future drug developmentthe testing of obesity drug candidates.
"The data generated thus far lays the groundwork for analysis of how individuals respond differently to disease," said Steven R. Smith, M.D., an expert in the obesity field and scientific director of the Florida Hospital Sanford-Burnham Translational Research Institute for Metabolism and Diabetes (TRI), where the Florida Hospital portion of the work is being performed. "This partnership with Takeda, TRI and Sanford-Burnham establishes a model to accelerate the development of safe and effective therapies."
During the first year of research, the modeling of fit and obese states laid the groundwork for discovery of a candidate drug for metabolic disease. Clinical research at the TRI assessed the physiological response to dietary changes, such as high sugar or high fat consumption. Across the translational bridge at Sanford-Burnham, patient-derived samples were analyzed using advanced technologies, such as metabolomics, to measure individual response. Ultimately, these metabolic fingerprints may serve as biomarkers and novel drug targets to project how subgroups of patients may respond to new therapies.
This bold collaborative research project involves combining the results of fundamental laboratory studies at Sanford-Burnham with parallel studies conducted with human samples by the research team at Florida Hospital. The results are reviewed on a regular basis in joint meetings of the basic laboratory team at Sanford-Burnham, the clinical research team at Florida Hospital, and the Takeda scientists in Shonan, Japan. Videoconferencing, together with semi-annual face-to-face meetings, have allowed for a stimulating exchange of ideas and efficient planning for next steps. The model serves as a high-profile example of how research institutes such as Sanford-Burnham can partner with industry to accelerate discovery of new drugs and diagnostic biomarkers relevant to common diseases such as obesity and diabetes that afflict populations worldwide.
"Our research projects have progressed extremely well and we were anxious to provide a research update to our partners in Japan," said Daniel Kelly, M.D., scientific director of Sanford-Burnham Medical Research Institute at Lake Nona. This was not, however, Takeda's first glimpse at the data. Researchers from Takeda, which is Japan's largest pharmaceutical company, met earlier this year in Orlando. A visiting Takeda scientist also works within the Sanford-Burnham laboratories. "This type of close collaboration during the fundamental discovery phase is part of a new model for academic-commercial partnerships designed to expedite new drug candidates into the development pipeline," said Dr. Kelly.
The partnership, launched in February 2011, aligns complementary strengths in biomedical research, clinical research, and drug development to identify and validate obesity-related biomarkers and new drug targets of mutual interest. The multi-disciplinary team of basic scientists and clinical researchers at Sanford-Burnham and the TRI provides Takeda with a research continuum from laboratory bench to patient bedside.
"We're optimistic that this collaboration will contribute to Takeda's goal of identifying novel targets that will lead to the development of new therapeutics to treat patients suffering from obesity," said Paul Chapman, Ph.D., general manager of Takeda's Pharmaceutical Research Division.
The partners expect that this research agreement will set the stage for future collaborative drug discovery programs aimed at novel therapeutics to treat obesity.
###
About Sanford-Burnham Medical Research Institute
Sanford-Burnham Medical Research Institute is dedicated to discovering the fundamental molecular causes of disease and devising the innovative therapies of tomorrow. The Institute consistently ranks among the top five organizations worldwide for its scientific impact in the fields of biology and biochemistry (defined by citations per publication) and currently ranks third in the nation in NIH funding among all laboratory-based research institutes. Sanford-Burnham is a highly innovative organization, currently ranking second nationally among all organizations in capital efficiency of generating patents, defined by the number of patents issued per grant dollars awarded, according to government statistics.
Sanford-Burnham utilizes a unique, collaborative approach to medical research and has established major research programs in cancer, neurodegeneration, diabetes, and infectious, inflammatory, and childhood diseases. The Institute is especially known for its world-class capabilities in stem cell research and drug discovery technologies. Sanford-Burnham is a U.S.-based, non-profit public benefit corporation, with operations in San Diego (La Jolla), Santa Barbara, and Orlando (Lake Nona). For more information, please visit our website (http://www.sanfordburnham.org) or blog (http://beaker.sanfordburnham.org). You can also receive updates by following us on Facebook and Twitter.
About the TRI
The Florida Hospital Sanford-Burnham Translational Research Institute for Metabolism and Diabetes (TRI) is the product of an innovative affiliation between Florida Hospital and Sanford-Burnham Medical Research Institute. By linking one of the largest not-for-profit hospitals in the country with a nationally renowned basic science leader, the TRI bridges the gap between the research bench and the patient's bedside. The mission of the TRI is to extend and improve the quality of lives through the translation of fundamental scientific discoveries to the diagnosis and treatment of human disease.
The TRI's new 54,000-square-foot, technologically advanced translational research facility is currently under construction at Florida Hospital's Health Village in Orlando and is expected to open in March 2012. Florida Hospital is a designated statutory teaching hospital and also trains physicians from all around the world in the newest technologies. For additional information, please visit http://www.TRI-MD.org or http://www.floridahospital.com.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Sanford-Burnham and Florida Hospital review obesity research progress with Takeda PharmaceuticalPublic release date: 15-Feb-2012 [ | E-mail | Share ]
Contact: Deborah Robison drobison@sanfordburnham.org 407-745-2073 Sanford-Burnham Medical Research Institute
The mid-term report lays groundwork for next phase of study
Orlando, Fla. February 15, 2012 Sanford-Burnham Medical Research Institute (Sanford-Burnham) and Florida Hospital researchers recently returned from Japan where they reviewed the progress that has been made at the mid-point of their research partnership with Takeda Pharmaceutical Company Limited (Takeda). The two-year collaboration focuses on the discovery and evaluation of new therapeutic approaches to obesity. The scientists reported benchmark data that sets the stage for a key element in future drug developmentthe testing of obesity drug candidates.
"The data generated thus far lays the groundwork for analysis of how individuals respond differently to disease," said Steven R. Smith, M.D., an expert in the obesity field and scientific director of the Florida Hospital Sanford-Burnham Translational Research Institute for Metabolism and Diabetes (TRI), where the Florida Hospital portion of the work is being performed. "This partnership with Takeda, TRI and Sanford-Burnham establishes a model to accelerate the development of safe and effective therapies."
During the first year of research, the modeling of fit and obese states laid the groundwork for discovery of a candidate drug for metabolic disease. Clinical research at the TRI assessed the physiological response to dietary changes, such as high sugar or high fat consumption. Across the translational bridge at Sanford-Burnham, patient-derived samples were analyzed using advanced technologies, such as metabolomics, to measure individual response. Ultimately, these metabolic fingerprints may serve as biomarkers and novel drug targets to project how subgroups of patients may respond to new therapies.
This bold collaborative research project involves combining the results of fundamental laboratory studies at Sanford-Burnham with parallel studies conducted with human samples by the research team at Florida Hospital. The results are reviewed on a regular basis in joint meetings of the basic laboratory team at Sanford-Burnham, the clinical research team at Florida Hospital, and the Takeda scientists in Shonan, Japan. Videoconferencing, together with semi-annual face-to-face meetings, have allowed for a stimulating exchange of ideas and efficient planning for next steps. The model serves as a high-profile example of how research institutes such as Sanford-Burnham can partner with industry to accelerate discovery of new drugs and diagnostic biomarkers relevant to common diseases such as obesity and diabetes that afflict populations worldwide.
"Our research projects have progressed extremely well and we were anxious to provide a research update to our partners in Japan," said Daniel Kelly, M.D., scientific director of Sanford-Burnham Medical Research Institute at Lake Nona. This was not, however, Takeda's first glimpse at the data. Researchers from Takeda, which is Japan's largest pharmaceutical company, met earlier this year in Orlando. A visiting Takeda scientist also works within the Sanford-Burnham laboratories. "This type of close collaboration during the fundamental discovery phase is part of a new model for academic-commercial partnerships designed to expedite new drug candidates into the development pipeline," said Dr. Kelly.
The partnership, launched in February 2011, aligns complementary strengths in biomedical research, clinical research, and drug development to identify and validate obesity-related biomarkers and new drug targets of mutual interest. The multi-disciplinary team of basic scientists and clinical researchers at Sanford-Burnham and the TRI provides Takeda with a research continuum from laboratory bench to patient bedside.
"We're optimistic that this collaboration will contribute to Takeda's goal of identifying novel targets that will lead to the development of new therapeutics to treat patients suffering from obesity," said Paul Chapman, Ph.D., general manager of Takeda's Pharmaceutical Research Division.
The partners expect that this research agreement will set the stage for future collaborative drug discovery programs aimed at novel therapeutics to treat obesity.
###
About Sanford-Burnham Medical Research Institute
Sanford-Burnham Medical Research Institute is dedicated to discovering the fundamental molecular causes of disease and devising the innovative therapies of tomorrow. The Institute consistently ranks among the top five organizations worldwide for its scientific impact in the fields of biology and biochemistry (defined by citations per publication) and currently ranks third in the nation in NIH funding among all laboratory-based research institutes. Sanford-Burnham is a highly innovative organization, currently ranking second nationally among all organizations in capital efficiency of generating patents, defined by the number of patents issued per grant dollars awarded, according to government statistics.
Sanford-Burnham utilizes a unique, collaborative approach to medical research and has established major research programs in cancer, neurodegeneration, diabetes, and infectious, inflammatory, and childhood diseases. The Institute is especially known for its world-class capabilities in stem cell research and drug discovery technologies. Sanford-Burnham is a U.S.-based, non-profit public benefit corporation, with operations in San Diego (La Jolla), Santa Barbara, and Orlando (Lake Nona). For more information, please visit our website (http://www.sanfordburnham.org) or blog (http://beaker.sanfordburnham.org). You can also receive updates by following us on Facebook and Twitter.
About the TRI
The Florida Hospital Sanford-Burnham Translational Research Institute for Metabolism and Diabetes (TRI) is the product of an innovative affiliation between Florida Hospital and Sanford-Burnham Medical Research Institute. By linking one of the largest not-for-profit hospitals in the country with a nationally renowned basic science leader, the TRI bridges the gap between the research bench and the patient's bedside. The mission of the TRI is to extend and improve the quality of lives through the translation of fundamental scientific discoveries to the diagnosis and treatment of human disease.
The TRI's new 54,000-square-foot, technologically advanced translational research facility is currently under construction at Florida Hospital's Health Village in Orlando and is expected to open in March 2012. Florida Hospital is a designated statutory teaching hospital and also trains physicians from all around the world in the newest technologies. For additional information, please visit http://www.TRI-MD.org or http://www.floridahospital.com.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
ScienceDaily (Feb. 14, 2012) ? Short-term exposure (for up to 7 days) to all major air pollutants, with the exception of ozone, is significantly associated with an increased risk of heart attack, according to a review and meta-analysis of previous studies appearing in the February 15 issue of JAMA.
The potentially harmful effect of episodes of high air pollution on health has been suspected for more than 50 years. "In industrialized countries, cardiovascular disease is the leading cause of mortality and is associated with significant morbidity. These countries have high pollution levels. Since the 1990s, many epidemiological studies have demonstrated associations between air pollution levels and human health in terms of hospital admissions and overall mortality, including respiratory or cardiovascular mortality. However, the association between air pollution and near-term risk of myocardial infarction [MI; heart attack] remains controversial. Some studies have shown an association, while other studies have found either no association or association only for selected pollutants," according to background information in the article.
Hazrije Mustafic, M.D., M.P.H., of the University Paris Descartes, INSERM Unit 970, Paris, and colleagues conducted a systematic review and meta-analysis to examine the association between short-term exposure to air pollutants and the risk of heart attack, and to quantify these associations. The major air pollutants included in the analysis were ozone, carbon monoxide, nitrogen dioxide, sulfur dioxide, and particulate matter (PM) with an aerodynamic diameter of 10 ?m (micrometers; PM10) or less and those 2.5 micrometers (PM2.5) or less.
The researchers conducted a search of the medical literature and identified 34 studies that met criteria for inclusion in the analysis, which indicated associations of statistical significance between all analyzed air pollutants and heart attack risk, with the exception of ozone. The subgroup analysis, based on study quality, yielded results comparable with those from the overall analysis.
The authors suggest a number of possible mechanisms for the associations found. "The first potential mechanism is inflammation. Studies have shown that levels of inflammatory markers such as C-reactive protein are higher as a result of exposure to air pollution. The second potential mechanism is abnormal regulation of the cardiac autonomic system. Several observational studies have linked high levels of air pollution with increased heart rate and decreased heart rate variability. The third possible mechanism is an increase in blood viscosity as a result of air pollution. This association can promote thrombus [blood clot] formation, accelerate the progression of atherosclerosis, and weaken the stability of atherosclerotic plaques."
The researchers acknowledge that the magnitude of association found in this study is relatively small compared with those of classic heart attack risk factors, such as smoking, hypertension, or diabetes. "Nevertheless, the population attributable fractions of each pollutant is not negligible because the majority of the population, including young and disabled patients, is exposed to air pollution, particularly in urban settings, and thus an improvement in air quality could have a significant effect on public health."
"In conclusion, our meta-analysis is the first to our knowledge to evaluate the quality and magnitude of associations between short-term exposure to major air pollutants and the risk of MI," the authors write. "Further research is needed to determine whether effective interventions that improve air quality are associated with a decreased incidence of MI."
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The above story is reprinted from materials provided by JAMA and Archives Journals.
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Journal Reference:
H. Mustafic, P. Jabre, C. Caussin, M. H. Murad, S. Escolano, M. Tafflet, M.-C. Perier, E. Marijon, D. Vernerey, J.-P. Empana, X. Jouven. Main Air Pollutants and Myocardial Infarction: A Systematic Review and Meta-analysis. JAMA: The Journal of the American Medical Association, 2012; 307 (7): 713 DOI: 10.1001/jama.2012.126
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
So you want to try your hand at home improvement, huh? Do you know anything about this kind of work? Do you know about all of the different kinds of tools and safety regulations? Do you know what entails a good job? If these questions raise more questions than you can answer, try looking at the tips below.
Roof Ideas
If you hate cleaning gutters or your home is surrounded by trees, consider installing a protective screen or guard over your gutters. These shields prevent leaves that have rolled down from your roof shingle tiles down into your gutters. They will allow water to drain from your roof efficiently. You may occasionally need to remove leaves from the exterior of the barriers, but you should not have to scoop pounds of nasty debris from the gutters themselves.
If the standpipe in your laundry room overflows when your washing machine drains, check for a clogged vent pipe (usually on your roof). You can also snake the drainpipe, as small socks or pocket debris may exit the washer and become trapped in the pipe. If no clogs are located, you may need to make the standpipe taller or replace it with a wider pipe that can handle your washer?s output.
If you?re doing home improvements to help the sale of a home, you must focus on aesthetics, but you should also have a home inspection, just in case something serious needs to be done, as well. If you can install a new roof or furnace, it will show the buyers that you were on top of your game and will permit you to command a higher price.
Hose down your home on the outside using a pressure washer and detergents made specifically for your siding. Pressure washers can be rented quite economically and they do wonders in cleaning the girt off the outside of your home. Be careful around the roof line and windows. You don?t want to knock anything loose!
When you are planning a roof replacement, make sure to consider using white tiles. Not only does this give your home a unique look, it also translates into keeping your home cooler. Roof tiles that are a lighter color attract less heat, which reduces the heat that builds up in your attic or upstairs floor. With white tiles, your house is sure to stay cooler during the hotter months of the year.
If space is at a premium in your home, consider remodeling the attic or basement. These areas offer a cost-effective way to gain extra square footage without resorting to constructing an addition. If the area already has a floor, roof, and walls your project will move along quickly and you?ll be enjoying your new space in no time.
Remember when doing a massive home renovation that the inside is not the only area that needs attention. Sure the inside of the home is a big factor in a major home improvement plan, but neglecting the outside will lead to expensive repairs down the road. Look at the roof, siding, paint, and gutters for any signs they need replacing.
A great way to save money is to look at different types of roof insulation for your next home improvement project. Various different types of insulation have been developed over the last few years that work even better than plain fiberglass insulation. A couple of examples are foam that covers the underside of the roof deck, and panels that are cut and laid out to reflect the heat before it even reaches your attic space.
To prevent a leaky roof make sure you do routine inspections for possible problems. You should do this after and major weather disturbances such as a strong storm, heavy rain or wind, hail storms, or heavy snow. Once you have found any discrepancies make sure you act on them right away.
Try working on the curb appeal of your home. Try improving the outside of your home by having a nicely mowed lawn with trimmed edges. Add a few well-placed shrubs. Sweep your walkway. Get the the exterior walls and roof power washed. Make sure the windows are gleaming. All of this can make a lasting impression when someone first sees your house.
Millions of homeowners decide every day to make some type of improvement to their homes, and many of them end up with poor results. Pay attention to the tips provided to you in this article so that you?re always making the best possible home improvement decisions when it?s time to spruce up your house.
Tim Knorr is a NJ roofing expert. He has done everything from project managing new office buildings to installing roofs for the average homeowner. Tim is thoroughly familiar with home improvement in NJ and is an expert in new construction in NJ.
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Public release date: 15-Feb-2012
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